Could this comic book really end Islamophobia? : Initial press coverage of Ms. Marvel #1 as commodity activism

This poster provides an overview at the initial press coverage of the Marvel comic book Ms. Marvel #1 which features an Islamic superheroine located in New Jersey. The comic was released in 2013 and was upheld a progressive move in comics. The author interrogates the rhetoric used by various media sources to establish the comic as a form of commodity activism and how this media coverage achieves this effect through the use of assimilationist and neoliberal rhetoric. The author finds that popular media coverage of the comic establishes the social problem of Islamophobia and lack of diverse representation in comics, provides a product solution in the form of Ms. Marvel #1, then allows consumers to participate in a constructed socially aware identity on social media through the “IamMsMarvel” hashtag. This paper adds to existing literature on commodity activism, and how it can be constructed without an explicit branding of such by the company creating the commodity

Sedan Performance/Economy Rear Diffuser

This project consists of designing in SolidWorks a model of the performance/fuel economy diffuser. The design is modeled with an Ahmed body (recommended shape for CFD testing vehicles) and the diffuser will be applied to the bottom of the rear bumper of the car. After this is done the model will be imported into ANSYS for CFD testing. Testing entails importing the model, then creating a mesh around the model, and then setting up the program to run analysis for calculating the coefficient of drag. Then building this SolidWorks model as a full working prototype for actual road-testing purposes. With the results from road testing, theoretical calculations can be compared with actual results

The Curious Home

This book describes the work done by the Interaction Research Studio in the Equator Project. Equator was a six-year Interdisciplinary Research Collaboration, funded by the Engineering and Physical Sciences Research Council (EPSRC), that brought together researchers from eight British institutions and a variety of disciplines. The project ended in June 2007 and involved: University of Bristol University of Glasgow Lancaster University University of Nottingham Goldsmiths, University of London University of Southampton University of Sussex University College London The book was published to coincide with the opening of The Curious Home Exhibition at the Pacific Playhouse, London 2007

Threshold devices: looking out from the home

Threshold devices present information gathered from the home’s surroundings to give new views on the domestic situation. We built two prototypes of different threshold devices and studied them in field trials with participant households. The Local Barometer displays online text and images related to the home’s locality depending on the local wind conditions to give an impression of the sociocultural surroundings. The Plane Tracker tracks aircraft passing overhead and imagines their flights onscreen to resource an understanding of the home’s global links. Our studies indicated that the experiences they provided were compelling, that participants could and did interpret the devices in various ways, that their form designs were appropriate for domestic environments, that using ready- made information contributed to the richness of the experiences, and that situating the information they provided with respect to the home and its locality was important for the ways people engaged with them

The Plane Tracker (Overview)

The Plane Tracker is an example of a ‘threshold device’ that presents information gathered from the home’s surroundings to give new views on domestic circumstances. A focus on the home and its surroundings complements more traditional applications for domestic computing. Whereas conventional systems for the home focus on bringing placeless and generic content into the home, Threshold devices, in contrast, particularise content by linking it to the home’s physical location. Further examples of Threshold Devices include the ‘Drift Table’, the ‘Local Barometer’ and the ‘Video Window’

Local Barometer (Overview)

Threshold devices present information gathered from the home’s surroundings to give new views on the domestic situation. The Local Barometer displays online text and images related to the home’s locality depending on the local wind conditions to give an impression of the sociocultural surroundings

Primer and interviews: Molecular mechanisms of morphological evolution

The beauty of the developing embryo, and the awe that it inspires, lure many scientists into the field of developmental biology. What compels cells to divide, migrate, and morph into a being with a complex body plan? Evolutionary developmental biologists hold similar fascinations, with dynamics that take place on a grander timescale. How do phenotypic traits diverge over evolutionary time? This primer illustrates how a deep understanding of the basic principles that underlie developmental biology have changed how scientists think about the evolution of body form. The primer culminates in a conversation with David Stern, PhD, and Michael Shapiro, PhD, who discuss current topics in morphological evolution, why the field should be of interest to classic developmental biologists, and what lies ahead. Developmental Dynamics 239:3497–3505, 2010. © 2010 Wiley-Liss, Inc

The Loci of Evolution: How Predictable is Genetic Evolution?

Is genetic evolution predictable? Evolutionary developmental biologists have argued that, at least for morphological traits, the answer is a resounding yes. Most mutations causing morphological variation are expected to reside in the cis-regulatory, rather than the coding, regions of developmental genes. This “cis-regulatory hypothesis” has recently come under attack. In this review, we first describe and critique the arguments that have been proposed in support of the cis-regulatory hypothesis. We then test the empirical support for the cis-regulatory hypothesis with a comprehensive survey of mutations responsible for phenotypic evolution in multicellular organisms. Cis-regulatory mutations currently represent approximately 22% of 331 identified genetic changes although the number of cis-regulatory changes published annually is rapidly increasing. Above the species level, cis-regulatory mutations altering morphology are more common than coding changes. Also, above the species level cis-regulatory mutations predominate for genes not involved in terminal differentiation. These patterns imply that the simple question “Do coding or cis-regulatory mutations cause more phenotypic evolution?” hides more interesting phenomena. Evolution in different kinds of populations and over different durations may result in selection of different kinds of mutations. Predicting the genetic basis of evolution requires a comprehensive synthesis of molecular developmental biology and population genetics

The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model

There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens. A combination formulation of amikacin-fosfomycin is currently undergoing clinical testing although the exposure-response relationships of these drugs have not been fully characterized. The aim of this study was to describe the individual and combined antibacterial effects of simulated epithelial lining fluid exposures of aerosolized amikacin and fosfomycin against resistant clinical isolates of Pseudomonas aeruginosa (MICs of 16 mg/liter and 64 mg/liter) and Klebsiella pneumoniae (MICs of 2 mg/liter and 64 mg/liter) using a dynamic hollow-fiber infection model over 7 days. Targeted peak concentrations of 300 mg/liter amikacin and/or 1,200 mg/liter fosfomycin as a 12-hourly dosing regimens were used. Quantitative cultures were performed to describe changes in concentrations of the total and resistant bacterial populations. The targeted starting inoculum was 10(8) CFU/ml for both strains. We observed that neither amikacin nor fosfomycin monotherapy was bactericidal against P. aeruginosa while both were associated with rapid amplification of resistant P. aeruginosa strains (about 10(8) to 10(9) CFU/ml within 24 to 48 h). For K. pneumoniae, amikacin but not fosfomycin was bactericidal. When both drugs were combined, a rapid killing was observed for P. aeruginosa and K. pneumoniae (6-log kill within 24 h). Furthermore, the combination of amikacin and fosfomycin effectively suppressed growth of resistant strains of P. aeruginosa and K. pneumoniae In conclusion, the combination of amikacin and fosfomycin was effective at maximizing bacterial killing and suppressing emergence of resistance against these clinical isolates

Induction cisplatin–irinotecan followed by concurrent cisplatin–irinotecan and radiotherapy without surgery in oesophageal cancer: multicenter phase II FFCD trial

A recent phase I study showed that weekly cisplatin, irinotecan and concurrent radiotherapy can be administered with moderate toxicity in patients with oesophageal cancer. Patients with no prior treatment and oesophageal cancer stage I to III, performance status <3, caloric intake >1500 kcal day−1 were included. Chemotherapy, with cisplatin 30 mg m−2 and irinotecan 60 mg m−2, was administered at days 1, 8, 22, 29, and concurrently with radiotherapy at days 43, 50, 64 and 71. Radiotherapy was delivered with 50 or 50.4 Gy in 25 fractions/5 weeks. Forty-three patients were included, 10 stage I, 19 stage II and 14 stage III. Mean age was 59.2 years (range 44–79). A total of 30 out of 43 (69.8%) patients underwent all planned treatment. During induction chemotherapy, 14 severe toxicities of grade 3 or 4 in 10 patients (23.3%) were reported with 57.1% due to haematoxicity. During chemoradiotherapy, 31 severe toxicities of grade 3 or 4 with 64.5% due to haematotoxicity were reported in 18 patients. One toxic death occurred (diarrhoea grade 4). The complete clinical response rate was 58.1% (95% CI: 43.4–72.8%). Overall survival rate at 1 and 2 years was 62.8%, (95% CI, 58.3–77.3%) and 27.9% (95% CI, 13.4–41.3%), respectively. In conclusion, cisplatin–irinotecan–radiotherapy is an active and well-tolerated regimen feasible in out-patients